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Rams (+2) @ 49ers; Total 42.5

October 3, 2022

KICKOFF: 8:15 p.m. ET

KEY FACTS: The last time these teams met, the Rams rallied from 17-7 down in the fourth quarter to win the NFC title. Both defenses figure to have the edge again Monday, given the Niners’ loss of LT Trent Williams (ankle) and the Rams’ 25th rated offense. Jimmy G & Co. are trying to remove the stink from their 11-10 loss in Denver.

TRENDING: The underdog has covered an astounding seven straight in the series. But San Fran has covered five straight at Levi’s Stadium.