LOCATION: Mexico City
KICKOFF: 8:15 p.m. ET
KEY FACTS: The line has surged from 8 and the Total has dipped as reports surfaced that Kyler Murray (hamstring) could miss his second straight game. Backup Colt McCoy is 3-1 as a starter since 2021, and he was solid (26-for-37, 238 yards) in Arizona’s 27-17 win over the Rams last week. WR DeAndre Hopkins (hamstring) is also questionable.
TRENDING: The Cardinals have owned the 49ers, going 7-1-1 ATS in their last nine meetings. The Over ↗️ has hit in four straight Arizona games.