KICKOFF: 8:15 p.m. ET
KEY STATS: Week 5 starts with household-name QBs (Matt Ryan and Russell Wilson) struggling with a new franchise. These are the two lowest-scoring teams in the AFC, and neither will have its top RB: Jonathan Taylor (ankle) is week-to-week and Javonte Williams (knee) is done for the season, yielding to the butter-fingered Melvin Gordon.
TRENDING: The Under has hit in nine straight Colts games. Denver has covered five straight at home against teams with a losing record.
BOOST: Wilson to throw 1.5+ TDs +115 ➡️ +130
